翻訳と辞書 Words near each other ・ Inorodtsy ・ Inosaurus ・ Inoscavin ・ Inoscavin A ・ Inosculation ・ Inoshō-mae Station ・ Inosinate nucleosidase ・ Inosine ・ Inosine kinase ・ Inosine monophosphate synthase ・ Inosine nucleosidase ・ Inosine pranobex ・ Inosine-5′-monophosphate dehydrogenase ・ Inosinic acid ・ Inositol ・ Inositol (1,4,5) Trisphosphate-3- Kinase ・ Inositol 1-methyltransferase ・ Inositol 2-dehydrogenase ・ Inositol 3-alpha-galactosyltransferase ・ Inositol 3-kinase ・ Inositol 3-methyltransferase ・ Inositol 4-methyltransferase ・ Inositol monophosphatase ・ Inositol monophosphatase 1 ・ Inositol monophosphatase 2 ・ Inositol monophosphatase 3 ・ Inositol nicotinate ・ Inositol oxygenase ・ Inositol pentakisphosphate ・ Inositol phosphate Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Inositol (1,4,5) Trisphosphate-3- Kinase ： ウィキペディア英語版 Inositol (1,4,5) Trisphosphate-3- Kinase Inositol (1,4,5) Trisphosphate-3- Kinase (E.C.2.7.1.127) is an enzyme that facilitates a phospho-group transfer from ATP to 1D-myo-inositol 1,4,5-trisphosphate. The first evidence of this kinase was isolated in 1990 from rat brain, completing the inositol metabolism pathway. Since this isolation, 3 human isoforms have been found (A,B,C). This enzyme (all isoforms) plays a vital role in the calcium signalling pathway by terminating the propagation of the signal caused by IP3 by converting it to IP4. ITP3K is regulated directly by Calmodulin directly and Calcium-Calmodulin dependent kinase II, as well as PKA and PKC. ITP3K itself is being targeted in anti-cancer drug efforts. Also, because of its role in metabolism, ITP3K is involved in the therapeutic use of inositol when taken for bipolar disorder, panic disorder, prevention of Spina Bifida of fetuses, reduce the onset of diabetes in pregnant women, and decrease tumor size in lung cancer. == Discovery == It was first reported that inositol was metabolized and absorbed by the body in 1934; however, it was not until 1986 that the full metabolic pathway was theorized. It was not certain which kinase was responsible for the conversion of inositol (1,4,5) trisphosphate (abbreviated IP3) to inositiol (1,3,4,5)tetrakisphosphate (abbreviated IP4) until the first isolation of ITP3K in 1990.〔 It was later found in 1993 that IP3 is an important second messenger in cell signaling events like "including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling." 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Inositol (1,4,5) Trisphosphate-3- Kinase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.